- Miscellanenous
- Cushing Syndrome Associated Myopathy: It Is Time for a Change
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Martin Reincke
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Endocrinol Metab. 2021;36(3):564-571. Published online June 18, 2021
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DOI: https://doi.org/10.3803/EnM.2021.1069
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Abstract
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- Cushing syndrome is the result of excessive levels of glucocorticoids. Endogenous Cushing syndrome is rare with an incidence of two to three cases per million per year. Clinically, the presentation consists of a characteristic phenotype including skin symptoms and metabolic manifestations. A frequent co-morbidity with high impact on quality of life is Cushing syndrome associated myopathy. It characteristically affects the proximal myopathy, impairing stair climbing and straightening up. The pathophysiology is complex and involves protein degradation via the forkhead box O3 (FOXO3) pathway, intramuscular fat accumulation, and inactivity-associated muscle atrophy. Surgical remission of Cushing syndrome is the most important step for recovery of muscle function. Restoration depends on age, co-morbidities and postoperative insulin-like growth factor concentrations. At average, functionality remains impaired during the long-term compared to age and sex matched control persons. Growth hormone therapy in individuals with impaired growth hormone secretion could be an option but has not been proved in a randomized trial.
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Citations
Citations to this article as recorded by
- Long-Term Consequences of Cushing Syndrome: A Systematic Literature Review
Soraya Puglisi, Anna Maria Elena Perini, Cristina Botto, Francesco Oliva, Massimo Terzolo The Journal of Clinical Endocrinology & Metabolism.2024; 109(3): e901. CrossRef - The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4
Min-Ji Kim, Ibotombi Singh Sinam, Zerwa Siddique, Jae-Han Jeon, In-Kyu Lee Diabetes & Metabolism Journal.2023; 47(2): 153. CrossRef - Intelligent Systems for Muscle Tracking: A Review on Sensor‐Algorithm Synergy
Arjun Putcha, Tien Nguyen, Regina Smith, Rachel Choffin, Wubin Bai Advanced Intelligent Systems.2023;[Epub] CrossRef - Sarcopenia in youth
Han Na Jung, Chang Hee Jung, You-Cheol Hwang Metabolism.2023; 144: 155557. CrossRef - Cushing Syndrome
Martin Reincke, Maria Fleseriu JAMA.2023; 330(2): 170. CrossRef - Musculoskeletal complications of Cushing syndrome
Dorota Leszczyńska, Alicja Szatko, Lucyna Papierska, Wojciech Zgliczyński, Piotr Glinicki Rheumatology.2023; 61(4): 271. CrossRef - Circulating myomiRNAs as biomarkers in patients with Cushing’s syndrome
C. Pivonello, R. Patalano, C. Simeoli, T. Montò, M. Negri, F. Amatrudo, N. Di Paola, A. Larocca, E. M. Crescenzo, R. Pirchio, D. Solari, C. de Angelis, R. S. Auriemma, L. M. Cavallo, A. Colao, R. Pivonello Journal of Endocrinological Investigation.2023; 47(3): 655. CrossRef - Low-grade inflammation during the glucocorticoid withdrawal phase in patients with Cushing's syndrome
Frederick Vogel, Leah Braun, Stephanie Zopp, Elisabeth Nowak, Jochen Schreiner, Irina Benz, German Rubinstein, Heike Künzel, Katrin Ritzel, Matthias Kroiss, Jürgen Honegger, Felix Beuschlein, Katharina Schilbach, Daniel Teupser, Martin Bidlingmaier, Marti European Journal of Endocrinology.2023; 188(4): 375. CrossRef - An odd case of immune-mediated necrotizing myopathy, complicated with sagittal, transverse and sigmoid sinus thrombosis
Andreea Trandafir, Violeta Claudia Bonjincă, Delia Tulba, Gelu Onose Balneo and PRM Research Journal.2023; 14(Vol.14, no): 630. CrossRef - Morbidität und Mortalität beim Cushing-Syndrom
Frederick Vogel, Leah Braun, Martin Reincke Der Internist.2022; 63(1): 34. CrossRef - Pathophysiology of Mild Hypercortisolism: From the Bench to the Bedside
Vittoria Favero, Arianna Cremaschi, Chiara Parazzoli, Alberto Falchetti, Agostino Gaudio, Luigi Gennari, Alfredo Scillitani, Fabio Vescini, Valentina Morelli, Carmen Aresta, Iacopo Chiodini International Journal of Molecular Sciences.2022; 23(2): 673. CrossRef - Long‐term morbidity and mortality in patients with Cushing's syndrome
Leah T. Braun, Frederick Vogel, Martin Reincke Journal of Neuroendocrinology.2022;[Epub] CrossRef - Clinical presentation and etiology of Cushing's syndrome: Data from ERCUSYN
Elena Valassi Journal of Neuroendocrinology.2022;[Epub] CrossRef - Pyruvate dehydrogenase kinase 4 promotes ubiquitin–proteasome system‐dependent muscle atrophy
Ibotombi Singh Sinam, Dipanjan Chanda, Themis Thoudam, Min‐Ji Kim, Byung‐Gyu Kim, Hyeon‐Ji Kang, Jung Yi Lee, Seung‐Hoon Baek, Shin‐Yoon Kim, Bum Jin Shim, Dongryeol Ryu, Jae‐Han Jeon, In‐Kyu Lee Journal of Cachexia, Sarcopenia and Muscle.2022; 13(6): 3122. CrossRef - Consensus on diagnosis and management of Cushing's disease: a guideline update
Maria Fleseriu, Richard Auchus, Irina Bancos, Anat Ben-Shlomo, Jerome Bertherat, Nienke R Biermasz, Cesar L Boguszewski, Marcello D Bronstein, Michael Buchfelder, John D Carmichael, Felipe F Casanueva, Frederic Castinetti, Philippe Chanson, James Findling The Lancet Diabetes & Endocrinology.2021; 9(12): 847. CrossRef
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